https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25826 PubMed and SCOPUS up to September 2015. Eligibility Criteria: RCTs comparing LIA with placebo or no infiltration after primary TKA in terms of pain score and opioid consumption at 24 and 48 h, mobilisation, LOS and complications were included. Results: In total 38 RCTs were included. LIA groups had lower pain scores, opioid consumption and postoperative nausea and vomiting, higher range of motion at 24 h and shorter LOS than no injection or placebo. After subgroup analysis, intraoperative peri-articular but not intra-articular injection had lower pain score at 24 h than no injection or placebo with the pooled mean difference of pain score at rest of -0.89 [95% CI (-1.40 to -0.38); I²=92.0%]. Continuing with postoperative injection or infusion reduced 24-h pain score with the pooled mean difference at rest of -1.50 [95% CI (-1.92 to -1.08); I²=60.5%]. There was no additional benefit in terms of pain relief during activity, opioid consumption, range of movement or LOS when LIA was used as an adjunct to regional anaesthesia. Four out of 735 patients receiving LIA reported deep knee infection, three of whom had had postoperative catheter placement. Conclusion: LIA is effective for acute pain management after TKA. Intraoperative peri-articular but not intra-articular injection may be helpful in pain control up to 24 h. The use of postoperative intra-articular catheter placement is still inconclusive. The benefit of LIA as an adjunctive treatment to regional anaesthesia was not demonstrated.]]> Sat 24 Mar 2018 07:34:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30722 r = −0.719, P < .01). Health care professionals must consider patients’ demographic characteristics when providing education and support regarding pain self-management for postoperative pain control.]]> Sat 24 Mar 2018 07:32:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27220 Sat 24 Mar 2018 07:32:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24703 Sat 24 Mar 2018 07:10:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34862 Mon 23 Sep 2019 10:23:44 AEST ]]>